Scutellaria lateriflora L. (Blue skullcap) is a perennial herb native to North America with a long traditional use to relieve anxiety and improve mood.
Recent studies suggest neuroprotective and anxiolytic effects.
It is a rich source of constituents with known biological activity:
● Flavonoids (baicalin, baicalein, wogonoside, wogonin)
● Diterpenoids (scutelaterin A, B, and C)
● Phenylpropanoids (caffeic acid, cinnamic
acid, coumaric acid, ferulic acid)
● Essential oils (terpenoids)
● Amino acids and melatonin
BlueCALM® by the Italian company EPO, specialist in botanical extracts since 1933, has strong antioxidant activity showing a significant dose-dependent radical scavenger activity in different experimental models.
BlueCALM® has shown anti-glycation activity: it inhibits the formation of AGEs (Advanced glycation end products), some harmful substances deriving from the combination of proteins and fats with sugars, that are involved in many chronic degenerative diseases, including Alzheimer’s, and in aging. These results may support the plant’s neuroprotective effects, already reported by available scientific data.
Improves mild anxiety and insomnia
BlueCALM® has been tested on a human adrenocortical carcinoma cell line, an in vitro model commonly used to investigate the mechanism of action of molecules with anti-anxiety activity. BlueCALM® significatively inhibits the release of cortisol, the body main "stress hormone".